Nothing tells the story of a young woman, named Jane, who is tired and worn out. She has resigned herself to her sad existence of a life with a man that she doesn't love and a dead-end job as a maid in a small rundown motel. Her one form of escape is to try on the lives of the guests that are staying in the rooms she cleans. As Jane reluctantly cleans while dabbling in her role playing game, she comes face to face with her own life, in a frightening and honest way. Set in the heat-soaked town of Twentynine Palms, the desert landscape becomes a character, and the film rides the line between art and narrative.